Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159
β Scribed by Tae Young Oh; Kyung Koo Kang; Byoung Ok Ahn; Moohi Yoo; Won Bae Kim
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 614 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0253-6269
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π SIMILAR VOLUMES
## Abstract Various factors influencing the protein binding of DAβ8159 to 4% human serum albumin (HSA) were evaluated using an equilibrium dialysis technique at an initial DAβ8159 concentration of 5 Β΅g/mL. It took approximately 8 h incubation to reach an equilibrium between 4% HSA and an isotonic p
## Abstract The changes in pharmacokinetics of DAβ8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DAβ8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentrationβ
## Abstract The subacute toxicities (10 male and 10 female rats at each dose) and the toxicokinetics (5 male rats at each dose) of DAβ8159, a new phosphodiesterase type V (PDE V) inhibitor, were evaluated after single (at day 1) and 4βweek (at day 28) oral administration of the drug at doses of 0 (