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Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

โœ Scribed by GOLDIN, A.; VENDITTI, J. M.; KLINE, I.; MANTEL, N.

Book ID
109653698
Publisher
Nature Publishing Group
Year
1966
Tongue
English
Weight
336 KB
Volume
212
Category
Article
ISSN
0028-0836

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX