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ER stress signaling by regulated splicing: IRE1/HAC1/XBP1

✍ Scribed by Sung Hoon Back; Martin Schröder; Kyungho Lee; Kezhong Zhang; Randal J. Kaufman

Book ID
116986560
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
476 KB
Volume
35
Category
Article
ISSN
1046-2023

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
✍ Hiderou Yoshida; Toshie Matsui; Akira Yamamoto; Tetsuya Okada; Kazutoshi Mori 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 544 KB

In yeast, the transmembrane protein kinase/endoribonuclease Ire1p activated by endoplasmic reticulum stress cleaves HAC1 mRNA, leading to production of the transcription factor Hac1p that activates the unfolded protein response (UPR). In mammals, no Hac1p counterpart has yet been discovered despite