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Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies

✍ Scribed by Castillo-Carranza, Diana L. (author);Zhang, Yan (author);Guerrero-Muñoz, Marcos J. (author);Kayed, Rakez (author);Rincon-Limas, Diego E. (author);Fernandez-Funez, Pedro (author)

Book ID
113077032
Publisher
Springer
Year
2012
Tongue
English
Weight
600 KB
Volume
37
Category
Article
ISSN
0364-3190

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In yeast, the transmembrane protein kinase/endoribonuclease Ire1p activated by endoplasmic reticulum stress cleaves HAC1 mRNA, leading to production of the transcription factor Hac1p that activates the unfolded protein response (UPR). In mammals, no Hac1p counterpart has yet been discovered despite