XBP1 mRNA Is Induced by ATF6 and Spliced
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Hiderou Yoshida; Toshie Matsui; Akira Yamamoto; Tetsuya Okada; Kazutoshi Mori
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Article
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2001
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Elsevier Science
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English
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In yeast, the transmembrane protein kinase/endoribonuclease Ire1p activated by endoplasmic reticulum stress cleaves HAC1 mRNA, leading to production of the transcription factor Hac1p that activates the unfolded protein response (UPR). In mammals, no Hac1p counterpart has yet been discovered despite