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Epstein-barr virus-induced malignant lymphoma in a white-lipped marmoset

✍ Scribed by Syam K. Sundar; Paul H. Levine; Dharam V. Ablashi; Sergio A. Leiseca; Gary R. Armstrong; John L. Cicmanec; George A. Parker; Meihan Nonoyama

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
585 KB
Volume
27
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

One of six white‐lipped marmosets inoculated with cell‐free B95‐8 virus developed diffuse malignant lymphoma. Epstein‐Barr virus (EBV) DNA was detected in a pathologically enlarged mandibular lymph node by DNA‐DNA hybridization. The affected animal at the time of killing had EBV antibody titers of 1:320 for viral capsid antigen (VCA) and 1:20 for early antigen (EA) while all non‐diseased animals had ≦1:80 VCA antibody and no detectable EA antibody. This is the first report of lymphoma development in a white‐lipped marmoset following EBV inoculation.

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