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Epstein-barr virus (EBV)-induced lymphoproliferative disease in cotton-topped marmosets

✍ Scribed by Donald R. Johnson; Lauren G. Wolfe; Göran Levan; George Klein; Ingemar Ernberg; Pierre Åaman

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
758 KB
Volume
31
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Six cotton‐topped marmoset monkeys (Sangiunus oedipus) were inoculated with 10^5^ tranforming units of B95‐8 virus, and two of them developed fatal lymphoproliferative disease. The EBV‐carrying tumor cells from these marmosets had the following characteristics: (I) they were polyclonal by surface immunoglobulin and immunoglobulin production in vitro; (2) they had no specific chromosome abnormalities, and (3) they failed to form colonies in large percentages in agarose. It is proposed that a spectrum of phenotypes of EBV‐induced lympho‐proliferative diseases in the cotton‐topped marmosets may be identified and are more akin to fatal infectious mononucleosis or X‐linked lymphoproliferative syndrome than to Burkitt's lymphoma.

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