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EPR Study of the Interactions between Dendrimers and Peptides Involved in Alzheimer's and Prion Diseases

✍ Scribed by Barbara Klajnert; Michela Cangiotti; Sara Calici; Jean Pierre Majoral; Anne Marie Caminade; Josep Cladera; Maria Bryszewska; Maria Francesca Ottaviani

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
448 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Spin‐probe and spin‐label techniques were used to study the interactions of the AΞ² 1–28 peptide involved in Alzheimer disease and the PrP 106–126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computer‐aided EPR analysis of a positively charged and a neutral spin probe was performed by comparing the pure dendrimer and peptide systems with the dendrimer‐peptide ones. Also spin‐labeled PAMAM dendrimers were used to test the interactions. The results show the interactions between dendrimer and peptide monomer to be stronger for AΞ² 1–28 than for PrP 106–126. PAMAM dendrimers perturb the aggregation of the peptides more than PPI dendrimers do.

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