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Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case-control studies

✍ Scribed by C. M. Van Duijn; D. G. Clayton; V. Chandra; L. Fratiglioni; A. B. Graves; A. Heyman; A. F. Jorm; E. Kokmen; K. Kondo; J. A. Mortimer; W. A. Rocca; S. L. Shalat; H. Soininen; A. Hofman

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
820 KB
Volume
11
Category
Article
ISSN
0741-0395

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✦ Synopsis

To study the interaction among genetic and environmental risk factors, a reanalysis of case-control studies of Alzheimer's disease (AD) was conducted based on the original data of all studies carried out to January 1, 1990. Seven studies were included in the present analysis, comprising a total of 814 AD patients and 894 control subjects. When comparing those with a positive and negative family history of dementia, similar odds ratio were found for late maternal age [ 1.7; 95% confidence interval (0.64.8) vs. 2.0 (1.1-3.5)], head trauma [ 1.7 (0.7-4.2) vs. 1.9

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