Epoxidation of alantolactone and isoalantolactone
β Scribed by A. T. Kulyyasov; T. S. Seitembetov; K. M. Turdybekov; S. M. Adekenov
- Book ID
- 105169313
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 258 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0009-3130
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In our total synthesis of (f)-artemlsin (1)l). (f)->oxo-8g(H),lla(H)-eudesmken-8,13\_ollde (17) was a key compound, and this contribution Is concerned with a successful synthesis of the optically active modlflcatlon of this compound from (+)-lsoalantolactone (2).and (+)-alantolactone (3)2) as well a
## Analysis of the 'H-'H NOE effects observed for S-(11,13-dihydroalantolacton-13-yl)-~-cysteinyl-~-alanine methyl ester in (CD3),S0 at 14 T showed that the 7-and ll-protons are in cis positions. The distances between 7-, 8-and ll-protons of the adduct were derived by a semi-quantitative approach