Structure of the Adduct of Alantolactone with (Z)-L-Cys-Ala-OMe; 1H and 13C Assignment of the Alantolactone Moiety by NMR at 14 T
✍ Scribed by Mauro Ginanneschi; Mario Chelli; Anna Maria Papini; Daniela Pinzani; Gianfranco Rapi
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 434 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Analysis of the 'H-'H NOE
effects observed for S-(11,13-dihydroalantolacton-13-yl)-~-cysteinyl-~-alanine methyl ester in (CD3),S0 at 14 T showed that the 7-and ll-protons are in cis positions. The distances between 7-, 8-and ll-protons of the adduct were derived by a semi-quantitative approach based on analysis of NOESY cross peaks and a computed molecular model. The simulated 'H spectrum of the alantolactone moiety is in excellent agreement with the experimental data. The complete assignments of the "C signals of alantolactone, its peptide adduct and four dipeptide precursors are based on one-and two-dimeusional 'H-% NMR techniques.