Conversion of (+)-isoalantolactone and (+)-alantolactone into (−)-artemisin

✍ Scribed by Koichiro Naemura; Masao Nakazaki

• Book ID: 104248512
• Publisher: Elsevier Science
• Year: 1969
• Tongue: French
• Weight: 210 KB
• Volume: 10
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)97645-2

✦ Synopsis

In our total synthesis of (f)-artemlsin (1)l). (f)->oxo-8g(H),lla(H)-eudesmken-8,13_ollde (17) was a key compound, and this contribution Is concerned with a successful synthesis of the optically active modlflcatlon of this compound from (+)-lsoalantolactone (2).and (+)-alantolactone (3)2) as well as Its conversion Into natural (-)-artemlsln (1).