Epistasis analysis for quantitative traits by functional regression model
β Scribed by Zhang, F.; Boerwinkle, E.; Xiong, M.
- Book ID
- 123609377
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2014
- Tongue
- English
- Weight
- 953 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1088-9051
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We study a population genetics model of an organism with a genome of ΒΈRMR loci that determine the values of ΒΉ quantitative traits. Each trait is controlled by a subset of ΒΈloci assigned randomly from the genome. There is an optimum value for each trait, and stabilizing selection acts on the phenotyp
## Abstract Efficient score tests for a twoβlocus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalenc
## Abstract Use of the regressive models to account for residual familial correlations in linkage analysis of complex quantitative traits can increase the power to detect linkage. This is especially observed when the effect of the gene to be mapped is small or when the residual correlations are sub