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Score tests for epistasis models on quantitative traits using general pedigree data

✍ Scribed by Kai Wang

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 172 KB
Volume: 25
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.10266

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✦ Synopsis

Abstract

Efficient score tests for a two‐locus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalency to their respective likelihood ratio tests and efficiency in computation. The finite‐sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed. Genet Epidemiol 25:314–326, 2003. © 2003 Wiley‐Liss, Inc.

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