✦ LIBER ✦

Use of the regressive models in linkage analysis of quantitative traits

✍ Scribed by Dr. Florence Demenais; Mark Lathrop

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 358 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100643

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Use of the regressive models to account for residual familial correlations in linkage analysis of complex quantitative traits can increase the power to detect linkage. This is especially observed when the effect of the gene to be mapped is small or when the residual correlations are substantial. © 1993 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Multipoint oligogenic linkage analysis o

Multipoint oligogenic linkage analysis of quantitative traits

✍ John Blangero; Laura Almasy 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 2 views

We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic a

Bayesian modelling of multivariate quant

Bayesian modelling of multivariate quantitative traits using seemingly unrelated regressions

✍ Claudio J. Verzilli; Nigel Stallard; John C. Whittaker 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 1 views

## Abstract We investigate a Bayesian approach to modelling the statistical association between markers at multiple loci and multivariate quantitative traits. In particular, we describe the use of Bayesian Seemingly Unrelated Regressions (SUR) whereby genotypes at the different loci are allowed to

Genetic Analysis of Complex Diseases ||

Genetic Analysis of Complex Diseases || Quantitative Trait Linkage Analysis

✍ Haines, Jonathan L.; Pericak-Vance, Margaret 📂 Article 📅 2006 🏛 John Wiley & Sons, Inc. ⚖ 256 KB 👁 2 views

Multipoint linkage analysis of quantitat

Multipoint linkage analysis of quantitative traits on sex-chromosomes

✍ Claus Thorn Ekstrøm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 1 views

## Abstract Variance component models form a powerful and flexible tool for multipoint linkage analysis of quantitative traits. Estimates of genetic similarity are needed for the variance component model to detect linkage and to locate genes, and two methods are commonly used to calculate multipoin

Dissecting the heterogeneity of rheumato

Dissecting the heterogeneity of rheumatoid arthritis through linkage analysis of quantitative traits

✍ Lindsey A. Criswell; Wei V. Chen; Damini Jawaheer; Raymond F. Lum; Mark H. Wener 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB 👁 1 views

## Abstract ## Objective To dissect the heterogeneity of rheumatoid arthritis (RA) through linkage analysis of quantitative traits, specifically, IgM rheumatoid factor (IgM‐RF) and anti–cyclic citrullinated peptide (anti‐CCP) autoantibody titers. ## Methods Subjects, 1,002 RA patients from 491 m

Quantitative trait linkage analysis by g

Quantitative trait linkage analysis by generalized estimating equations: Unification of variance components and Haseman-Elston regression

✍ Wei-Min Chen; Karl W. Broman; Kung-Yee Liang 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 1 views

## Abstract Two of the major approaches for linkage analysis with quantitative traits in humans include variance components and Haseman‐Elston regression. Previously, these were viewed as quite separate methods. We describe a general model, fit by use of generalized estimating equations (GEE), for