Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests
β¦ LIBER β¦
Epigenetic regulation of MHC-II and CIITA genes
β Scribed by Kenneth L. Wright; Jenny P-Y. Ting
- Book ID
- 116577792
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 390 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1471-4906
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## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1β3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type