✦ LIBER ✦

Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes

✍ Scribed by Eleni Zika; Jenny P-Y Ting

Book ID: 104014381
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 180 KB
Volume: 17
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2004.11.008

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✦ Synopsis

Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion. MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter.

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