In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno
Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes
✍ Scribed by Salomé LeibundGut-Landmann; Jean-Marc Waldburger; Michal Krawczyk; Luc A. Otten; Tobias Suter; Adriano Fontana; Hans Acha-Orbea; Walter Reith
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 227 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0014-2980
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Activation of T lymphocytes is quantitatively controlled by the level of expression of MHC class II molecules. Both constitutive and inducible expression of MHC class II genes is regulated by the transactivator CIITA, which is itself tightly regulated. Since the level of MHC class II molecules expre
We have established a gene regulatory system in mice by the inducible anti-sense RNA. We have generated transgenic mice carrying the anti-sense DNA composed of the class II MHC gene under the control of the human metallothionein IIa gene promoter. The detectable amount of anti-sense RNA was constitu
Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-.I) treatment led