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Epigenetic Regulation of Gelsolin Expression in Human Breast Cancer Cells

✍ Scribed by Lawrence M. Mielnicki; Angela M. Ying; Karen L. Head; Harold L. Asch; Bonnie.B. Asch

Book ID: 115603279
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 375 KB
Volume: 249
Category: Article
ISSN: 0014-4827
DOI: 10.1006/excr.1999.4461

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Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most