## Abstract ## Background To evaluate epidermal growth factor receptor (EGFR) phenotypic expression and related gene status in malignant pleural mesothelioma (MPM) and to correlate the results with patients' prognosis. ## Method Eightyβthree cases of MPM specimens were submitted to immunohistoch
Epidermal growth factor receptor gene mutation, amplification and protein expression in malignant pleural mesothelioma
β Scribed by K. Okuda; H. Sasaki; O. Kawano; H. Yukiue; T. Yokoyama; M. Yano; Y. Fujii
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 359 KB
- Volume
- 134
- Category
- Article
- ISSN
- 1432-1335
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We studied epidermal growth factor receptor (EGFR) gene amplification and expression in 11 early passage human head and neck carcinoma cell lines. Three cell lines demonstrated EGFR gene amplification and 10 lines showed an increase in EGFR mRNA when compared with normal keratinocytes, placenta, and
## Abstract ## BACKGROUND. Erlotinib, in combination with gemcitabine, has shown clinical benefits in pancreatic adenocarcinoma patients. The presence of __EGFR__ mutations and increased __EGFR__ copy numbers in pancreatic adenocarcinoma was explored. ## METHODS. Sixtyβsix pancreatic cancer pati