Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma
โ Scribed by Sarah Minner; Dorothea Rump; Pierre Tennstedt; Ronald Simon; Eike Burandt; Luigi Terracciano; Holger Moch; Waldemar Wilczak; Carsten Bokemeyer; Margit Fisch; Guido Sauter; Christian Eichelberg
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 995 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0008-543X
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We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (ECFR) gene and found gene amplification in one case of high-stag+high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression o