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Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations

✍ Scribed by Cai, C Q; Peng, Y; Buckley, M T; Wei, J; Chen, F; Liebes, L; Gerald, W L; Pincus, M R; Osman, I; Lee, P

Book ID
110072964
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
360 KB
Volume
27
Category
Article
ISSN
0950-9232

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Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it