Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor
โ Scribed by Stuart J. Decker
- Book ID
- 115763012
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 732 KB
- Volume
- 166
- Category
- Article
- ISSN
- 0006-291X
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Transforming growth factor-alpha (TGFโฃ) is an epidermal growth factor receptor (EGFR) ligand which is distinguished from EGF by its acid-labile structure and potent transforming function. We recently reported that TGFโฃ induces less efficient EGFR heterodimerization and downregulation than does EGF (
Epidermal growth factor (EGF) and transforming growth factor-~ (TGF-~) are polypeptides which bind to the EGF receptor (EGFr) and may play a role in cell growth and carcinogenesis. Our study investigated the content of EGF, TGF<z, and EGFr in tumors of the stomach and the colon in comparison with th