Cytosine arabinoside (Ara-C) is a very potent inhibitor of DNA synthesis in mammalian cells. This inhibition does not appear to be due to the direct inhibition of DNA polymerase by Ara-CTP (triphosphate of Ara-C) because it is a very weak competitive inhibitor of this enzyme. The inhibition of DNA s
β¦ LIBER β¦
Enzymology of cytosine arabinoside
β Scribed by Cheng, Yung-Chi ;Capizzi, Robert L.
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 308 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0098-1532
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β¦ Synopsis
The enzymes responsible for the metabolism of Ara-C and its metabolites in human cells are described. The relevance of the properties of those enzymes to the action of Ara-C is discussed.
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