๐”– Bobbio Scriptorium
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Biochemical pharmacology of cytosine arabinoside

โœ Scribed by Momparler, Richard L.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
268 KB
Volume
10
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

Cytosine arabinoside (Ara-C) is a very potent inhibitor of DNA synthesis in mammalian cells. This inhibition does not appear to be due to the direct inhibition of DNA polymerase by Ara-CTP (triphosphate of Ara-C) because it is a very weak competitive inhibitor of this enzyme. The inhibition of DNA synthesis appears to be due to the incorporation of Ara-C into DNA producing chain termination of polydeoxynucleotide elongation.

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