๐”– Bobbio Scriptorium
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Clinical pharmacology and human antitumor activity of cytosine arabinoside

โœ Scribed by Robert W. Talley; R. M. O'Bryan; W. G. Tucker; R. V. Loo

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
635 KB
Volume
20
Category
Article
ISSN
0008-543X

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Cytosine arabinoside (Ara-C) is a very potent inhibitor of DNA synthesis in mammalian cells. This inhibition does not appear to be due to the direct inhibition of DNA polymerase by Ara-CTP (triphosphate of Ara-C) because it is a very weak competitive inhibitor of this enzyme. The inhibition of DNA s

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Drug resistance is one of the major reasons for failure of chemotherapy of acute leukemia with cytosine arabinoside (AM-C). In order to overcome this problem we have investigated the interaction of ARA-C with 3-deazauridine (3-DU) against HL-60 myeloid leukemic cells. 3-DU is an interesting agent to