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Enzymic kinetic resolution of .alpha.-nitro .alpha.-methyl carboxylic acids

✍ Scribed by Lalonde, James J.; Bergbreiter, David E.; Wong, C. H.


Book ID
120544939
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
712 KB
Volume
53
Category
Article
ISSN
0022-3263

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Enantioselective synthesis of (R)- and (
✍ Paul V. Fish; Malcolm Mackenny; Gerwyn Bish; Timothy Buxton; Russell Cave; David πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 French βš– 163 KB

The (R)-and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and