Enzymic approach to the synthesis of the pyrrolo[1,4]benzodiazepine antibiotics
β Scribed by Kamal, Ahmed
- Book ID
- 115525326
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 545 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
hbama:. A new facile ffmlz~ of pyrrolo [2,l-c][l,4]bonzodazepne (PBD) ring system has been achieved by reductive cyclization of the azide ~naploying hexamethyldligilathiarlΒ’ (HMDST). pment mmul~ituted PBD and the natunfl product DC-81 have also been prepmed in good overall yields
The solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) imines and biologically important pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones on Wang resin using a reduction/cyclization procedure is reported.