Incompatibility of acid-labile 2′ and 5′
✍
Chris Christodoulou; Sudhir Agrawal; Michael J. Gait
📂
Article
📅
1986
🏛
Elsevier Science
🌐
French
⚖ 152 KB
Cleavage of 2'-0-tetrahydropyranyl groups from ribonucleoside derivatives used in solid-phase oligoribonucleotide synthesis takes place to an unacceptable extent during treatment with protic acid to remove 5'-O-pixyl groups.