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Novel oxidatively removable protecting groups and linkers for solid-phase synthesis of oligosaccharides

โœ Scribed by Koichi Fukase; Kenji Egusa; Yoshihiko Nakai; Shoichi Kusumoto

Book ID
105286503
Publisher
Springer
Year
1997
Tongue
English
Weight
539 KB
Volume
2
Category
Article
ISSN
1381-1991

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The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.