Enzyme-cleavable linkers for peptide and glycopeptide synthesis
β Scribed by Maltman, Beatrice A.; Bejugam, Mallesham; Flitsch, Sabine L.
- Book ID
- 119963442
- Publisher
- Royal Society of Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 136 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B506154G
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π SIMILAR VOLUMES
Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue
This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and "small" organic molecules, as well as their limitations for particula