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Enzyme amperometric sensor for the determination of cholinesterase inhibitors or activators

✍ Scribed by S.S. Babkina; E.P. Medyantseva; H.C. Budnikov; V.G. Vinter

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
534 KB
Volume
273
Category
Article
ISSN
0003-2670

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✦ Synopsis

An enzyme amperometrlc sensor @AS) based on munoblhzed chohnesterase (ChE) sensltlve to ChE effeztors (both specific and non-spectic) IS shown to be useful m enzyme immunoassay For example, a mmk autommnme (Aleutian) &sease can be diagnosed mth the EAS when an antigen IS labelled Hnth a ChE mhlbltor When the ChE-contammg membrane is modlfied by mcorporatlon of the antigen to give an mnmmoenxyme EAS, thrs unmunoassay can be performed on the basis of the stenc shielding of the enxyme active sites wrth the tmmunocomplexes formed

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