๐”– Bobbio Scriptorium
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Enzymatic synthesis of Thia-L-tryptophans

โœ Scribed by Robert S. Phillips; Louis A. Cohen; Ulf Annby; David Wensbo; Salo Gronowitz


Book ID
103982943
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
112 KB
Volume
5
Category
Article
ISSN
0960-894X

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A convenient method for the synthesis of L-tryptophan analogues is described. The method utilizes E. coli tryptophan synthetase, which catalyses the condensation of indole and L-serine to yield L-tryptophan. It is found :hat several indole analogues will replace indole as substrate for the enzyme to

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## Abstract The enzymatic synthesis of lโ€tryptophan and its derivative 5โ€ฒโ€hydroxyโ€lโ€tryptophan labeled with deuterium and tritium at the ฮฑโ€carbon position is reported. The mixture containing __S__โ€methylโ€lโ€cysteine, indole or 5โ€hydroxyindole dissolved in deuteriated or tritiated water has been conv