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The enzymatic synthesis of l-tryptophan analogues

✍ Scribed by Michael Wilcox

Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
355 KB
Volume
59
Category
Article
ISSN
0003-2697

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✦ Synopsis

A convenient method for the synthesis of L-tryptophan analogues is described. The method utilizes E. coli tryptophan synthetase, which catalyses the condensation of indole and L-serine to yield L-tryptophan. It is found :hat several indole analogues will replace indole as substrate for the enzyme to give the corresponding L-tryptophan analogues in good yield. By using ['"Clserine, analogues can be prepared radioactively labeled in the side-chain carbon atoms.

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