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Transition Metal-Catalyzed Synthesis of Novel Biologically Relevant Tryptophan Analogues

✍ Scribed by Bart C. J. van Esseveldt; Floris L. van Delft; Jan M. M. Smits; René de Gelder; Hans E. Schoemaker; Floris P. J. T. Rutjes

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
400 KB
Volume
346
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A synthetic approach to the synthesis of novel tryptophan derivatives and benzofuran‐containing amino acids is detailed. The sequence starts from enzymatically resolved enantiopure acetylene‐containing amino acids, of which the acetylene function can be efficiently transformed into the targeted 2‐substited indole and benzofuran moieties via Sonogashira‐type coupling and metal‐catalyzed cyclization.

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