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Enzymatic synthesis of [ribose-U-14C]8-azaguanosine

✍ Scribed by Maria Grazia Tozzi; Marcella Camici; Antonella Del Corso; Pier Luigi Ipata

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 225 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580270506

No coin nor oath required. For personal study only.

✦ Synopsis

8-Azaguanosine

I4C-labeled in the ribose moiety was enzymatically synthesized in two steps:

2 ) synthesis of 8-azaguanosine from [ U-14C]ribose-l-phosphate and 8-azaguanine catalyzed by purine nucleoside phosphorylase. The radiochemical yield was 708, and no contaminants were present in the isolated radioactive nucleoside analog, as judged by HPLC analysis.

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