A series of phosphopeptides Tyr(POsH2)-Val-Pro-Xxx-Leu (Xxx = Met, Met(O), Nle, Dab or Cys), derived from the native platelet-derived growth factor-J3 receptor (PDGF-I3) sequence, has been prepared to study their interaction with the src-homology 2 (SH2) domains of the p85 subunit of PI3 kinase. The
β¦ LIBER β¦
Enzymatic synthesis of phosphotyrosine-containing peptides via adenylated intermediates
β Scribed by Gibson, Bradford W.; Hines, Wade; Yu, Zhonghua; Kenyon, George L.; McNemar, Linda; Villafranca, Joseph J.
- Book ID
- 127231442
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 764 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0002-7863
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## Abstract __Michael acceptors have long been recognized as reactive functionalities that may link a biologically active molecule to its cellular target. 1,2βDehydro amino acids are potential Michael acceptors present in a large number of natural products, but their reactivity is modulated by the