Asymmetric Synthesis of the Roche Ester
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Jeroen Wassenaar; Mark Kuil; Joost N.β
H. Reek
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Article
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2008
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John Wiley and Sons
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English
β 178 KB
π 2 views
## Abstract (__S__)β3βHydroxyβ2βmethylpropionate, known as the Roche ester, and several of its derivatives were successfully synthesized through asymmetric rhodiumβcatalyzed hydrogenation, using INDOLPHOS (diisopropyl{1β[(__S__)β3,5βdioxaβ4βphosphacyclohepta[2,1β__a__;3,4β__aβ²__]dinaphthalenβ4βyl]β