Synthesis and Enzymatic Digestion of an
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Elisabeth Moyroud; Ewa Biala; Peter Strazewski
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Article
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2000
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Elsevier Science
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French
β 243 KB
The d-and l-RNA nonamers of the sequence r(GCUUCGGC)T have been synthesised for X-ray crystallographic purposes. In vitro digestion of the unnatural optical antipode by snake venom phosphodiesterase I takes place at an approximately 1800-fold slower rate than that of the natural d-nonamer. The diges