Enzymatic Hydroxylation by Dopamine β-Hydroxylase

✍ Scribed by Anton A. Mitrochkine; Frank Eydoux; Gérard Gil; Marius Réglier

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 598 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199806)1998:6<1171::aid-ejoc1171>3.0.co;2-#

✦ Synopsis

O-O activation / C-H activation

The three-dimensional aspects of the chemistry of dopamine β-hydroxylase (DBH) was studied through a conformationally-restricted substrate analog approach. We found that the DBH-catalyzed hydroxylation of 2-aminoindane (1) exclusively produced the trans-(1S,2S)-2-amino-1-indanol