Plasma dopamine-β-hydroxylase in the diagnosis of neuroblastoma
✍ Scribed by Stanley G. Rockson; Richard A. Stone; Fred Odere; J. Caulie Gunnells
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 955 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Recent reports have suggested that elevations of serum dopamine‐B‐hydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the
A role for central norepinephrine is implicated in functional recovery after experimental brain injury. In this study, imunohistochemistry was used to examine tyrosine hydroxylase and dopamine-B-hydroxylase, enzymes involved in norepinephrine biosynthesis, in the locus coeruleus after lateral fluid
Dopamine -hydroxylase (E.C. 1.14.17.1; protein abbreviation: DH) catalyzes conversion of dopamine to norepinephrine. Previous work identified two expressed alleles of the gene encoding DH (locus symbol DBH), containing either G or T at nucleotide position 910, resulting in specification by codon
A new, highly sensitive, specific assay for dopamine-P-hydroxylase (DBH) activity in human serum is described. Tyramine is used as a substrate; the product of the enzymatic hydroxylation, octopamine, is converted by reacting with I-dimethylaminonaphthalene-5-sulfonyl-chloride (Dns-Cl) to a fluoresce