Enzymatic Defects of Heme Synthesis In Thalassemia
β Scribed by M. Steiner; M. Baldini; W. Dameshek
- Book ID
- 114877666
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 564 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0890-6564
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l-threo-Hydroxyaspartic acid (l-THA, 1), the b-hydroxylated form of l-aspartic acid (2), is of current medicinal interest because it inhibits l-asparagine synthetase, [1] is a key constituent of several proteins in the blood-clotting cascade, [2] and inhibits the function of excitatory amino acid (E
Homozygosity for the South-Asian β£thalassemia (--SEA /) deletion is a serious hematological condition that results, in most cases, in intrauterine or postnatal death due to anemia and severe hypoxia of prenatal onset. A relationship between congenital abnormalities and intra-uterine hypoxia has been