✦ LIBER ✦

Non-Heme Hydroxylase Engineering For Simple Enzymatic Synthesis of L-threo-Hydroxyaspartic Acid

✍ Scribed by Matthias Strieker; Lars-Oliver Essen; Christopher T. Walsh; Mohamed A. Marahiel

Book ID: 101823212
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 262 KB
Volume: 9
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200700557

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✦ Synopsis

l-threo-Hydroxyaspartic acid (l-THA, 1), the b-hydroxylated form of l-aspartic acid (2), is of current medicinal interest because it inhibits l-asparagine synthetase, [1] is a key constituent of several proteins in the blood-clotting cascade, [2] and inhibits the function of excitatory amino acid (EAA) transporters as an

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