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Entropically Driven Enhancement of Cleavage Activity of a DNA-Armed Hammerhead Ribozyme: Mechanism of Action of Hammerhead Ribozymes

✍ Scribed by Warashina, Masaki; Takagi, Yasuomi; Sawata, Shinya; Zhou, De-Min; Kuwabara, Tomoko; Taira, Kazunari

Book ID
125942973
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
204 KB
Volume
62
Category
Article
ISSN
0022-3263

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Cleavage activity of a hammerhead ribozy
Cleavage activity of a hammerhead ribozyme domaincontaining 2β€²,5β€²-phosphodiester linkages
✍ Fabienne Burlina; Jean-Louis Fourrey; ValΓ©rie Lefort; Alain Favre πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 317 KB

The effects of the introduction of 2',5'-phosphodiester linkages within a hammerhead ribozyme domain have been examined in order to determine the regions which can be modified without impairing the cleavage activity and whether a substrate analogue, containing a 2',5'-linkage at the scissile positio