Enhancement of ultraviolet-induced mutation in bacteria by caffeine
β Scribed by Margaret Lieb
- Publisher
- Springer
- Year
- 1961
- Tongue
- English
- Weight
- 950 KB
- Volume
- 92
- Category
- Article
- ISSN
- 1617-4615
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## Abstract Strains deficient in recombinational repair (__recA^β^__) failed to be reverted by MNNG. Caffeine was found to efficiently repress MNNGβinduced reversions with proficient and deficient (__uvrB^β^__) excision repair strains. The presence of the resistance plasmid pKM 101 had no influence
Inhibition of DNA repair by caffeine is manifested in Schizosaccharomyces pombe wild-type cells as an enhancement of UV- or gamma-irradiation-induced lethality. The progress of DNA repair processes involving one or more caffeine-sensitive steps may be conveniently followed by measuring the concomita
## Abstract Enhancement of host cell reactivation (HCR) of ultraviolet (UV)βirradiated herpes simplex virus (HSV) was demonstrated in cell cultures pretreated with caffeine, hydroxyurea, or 5βbromodeoxyuridine (Brd Urd). The effect of caffeine on HCR was shown to depend on the time of drug treatmen