Candida albicans exhibits greater susceptibility to inactivation by ultraviolet (uv) radiation if grown before or after irradiation at 37 ~ C rather than 25 ~ C. Caffeine, acriflavin or amino acid analogues potentiate inactivation during postirradiation growth at 37~ but have little effect at 25 ~ C
Relative susceptibilities of caffeine-sensitive and caffeine-resistant strains of Candida albicans to inactivation and mutation by ultraviolet radiation
โ Scribed by Sarachek, A. ;Bish, J. T. ;Ireland, Rosalee
- Publisher
- Springer-Verlag
- Year
- 1970
- Weight
- 770 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0003-9276
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## Abstract Nalidixic acid (Nal) can kill __Candida albicans__ directly or suppress the organism's recovery from ultraviolet irradiation. Mutants selected for resistance to inactivation by Nal alone have generally enhanced DNA repair proficiencies evidenced by their coincident increased resistances
Ultraviolet radiation is more effective than either ethyl methanesulfonate or nitrous acid in inducing reverse mutation from auxotrophy to prototrophy in C. albicans. The killing effect of each of the mutagens is greater for cells grown at 37 C than at 25 C after treatment; mutation frequencies are