Protection against infection with encapsulated bacteria is mediated by IgG antibodies against the capsular polysaccharides. Production of such antibodies is impaired during infancy, when susceptibility to bacterial meningitis is greatest. Recent studies have proposed the use of anti-CD40 antibody to
Enhancement of T cell-independent immune responses in vivo by CD40 antibodies
β Scribed by Dullforce, Per; Sutton, Debbie C.; Heath, Andrew W.
- Book ID
- 109926833
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 760 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1078-8956
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CD40 is expressed on a wide array of hematopoietic and non-hematopoietic cells, including keratinocytes. The pivotal in vivo function of CD40 on hematopoietic cells in the regulation of both humoral and cell-mediated immunity is well established. However, whether CD40 expression on non-hematopoietic
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