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Enhancement of cyclosporin a induced hepato-toxicity by glutathione depletion

✍ Scribed by Inselmann, G.; Lawerenz, U.; Heidemann, H.

Book ID
122534835
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
69 KB
Volume
13
Category
Article
ISSN
0168-8278

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Enhancement of etoposide-induced cytotox
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Following the clinical observation of enhanced antineoplastic action of etoposide in the presence of cyclosporin A (CyA), we investigated this drug interaction in several in vitro and in vivo tumor systems. Macromolecular DNA damage induced by etoposide at drug levels comparable to plasma AUC values