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Enhancement of chemically induced bladder carcinoma by cyclosporin A

✍ Scribed by F. Recker; H. Rübben; A. Homburg; F.-J. Deutz; H.-G. Sieberth; W. Lutzeyer

Book ID
115133941
Publisher
Springer
Year
1988
Tongue
English
Weight
514 KB
Volume
1
Category
Article
ISSN
0934-0874

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Following the clinical observation of enhanced antineoplastic action of etoposide in the presence of cyclosporin A (CyA), we investigated this drug interaction in several in vitro and in vivo tumor systems. Macromolecular DNA damage induced by etoposide at drug levels comparable to plasma AUC values