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Enhancement of cyclosporin A induced hepato- and nephrotoxicity by glutathione depletion

✍ Scribed by G. INSELMANN; H. U. LAWERENZ; U. NELLESSEN; H. T. HEIDEMANN

Book ID
114727329
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
489 KB
Volume
24
Category
Article
ISSN
0014-2972

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Following the clinical observation of enhanced antineoplastic action of etoposide in the presence of cyclosporin A (CyA), we investigated this drug interaction in several in vitro and in vivo tumor systems. Macromolecular DNA damage induced by etoposide at drug levels comparable to plasma AUC values